Our Research

Laboratory of virus-host dynamics at the cross-species interface.

We aim to better understand how viruses interact with the immune system and how they navigate species barriers. We develop new model systems to study antiviral immunity and cross-species virus infections in vitro and in vivo. To study this we use a newly developed model system to track viruses within both the reservoir and host animals, where we can perturb key components of the immune system in the host. We also take an unbiased approach evaluating barriers to virus infection in vitro using a “fibroblast zoo” across the biodiversity of mammals. We are also interested in understanding how influenza virus cellular and species tropism is controlled by antiviral response.